Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 61
Filtrar
2.
Heliyon ; 10(4): e26298, 2024 Feb 29.
Artículo en Inglés | MEDLINE | ID: mdl-38404892

RESUMEN

Electroencephalography (EEG) has been a fundamental technique in the identification of health conditions since its discovery. This analysis specifically centers on machine learning (ML) and deep learning (DL) methodologies designed for the analysis of electroencephalogram (EEG) data to categorize individuals with Alzheimer's Disease (AD) into two groups: Moderate or Advanced Alzheimer's dementia. Our study is based on a comprehensive database comprising 668 volunteers from 5 different hospitals, collected over a decade. This diverse dataset enables better training and validation of our results. Among the methods evaluated, the CNN (deep learning) approach outperformed others, achieving a remarkable classification accuracy of 97.45% for patients with Moderate Alzheimer's Dementia (ADM) and 97.03% for patients with Advanced Alzheimer's Dementia (ADA). Importantly, all the compared methods were rigorously assessed under identical conditions. The proposed DL model, specifically CNN, effectively extracts time domain features from EEG data in time, resulting in a significant reduction in learnable parameters and data redundancy.

3.
J Alzheimers Dis ; 95(4): 1667-1683, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37718814

RESUMEN

BACKGROUND: In pursuit of diagnostic tools capable of targeting distinct stages of Alzheimer's disease (AD), this study explores the potential of electroencephalography (EEG) combined with machine learning (ML) algorithms to identify patients with mild or moderate AD (ADM) and advanced AD (ADA). OBJECTIVE: This study aims to assess the classification accuracy of six classical ML algorithms using a dataset of 668 patients from multiple hospitals. METHODS: The dataset comprised measurements obtained from 668 patients, distributed among control, ADM, and ADA groups, collected from five distinct hospitals between 2011 and 2022. For classification purposes, six classical ML algorithms were employed: support vector machine, Bayesian linear discriminant analysis, decision tree, Gaussian Naïve Bayes, K-nearest neighbor and random forest. RESULTS: The RF algorithm exhibited outstanding performance, achieving a remarkable balanced accuracy of 93.55% for ADA classification and 93.25% for ADM classification. The consistent reliability in distinguishing ADA and ADM patients underscores the potential of the EEG-based approach for AD diagnosis. CONCLUSIONS: By leveraging a dataset sourced from multiple hospitals and encompassing a substantial patient cohort, coupled with the straightforwardness of the implemented models, it is feasible to attain notably robust results in AD classification.

4.
JACC Cardiovasc Interv ; 16(14): 1794-1803, 2023 07 24.
Artículo en Inglés | MEDLINE | ID: mdl-37495352

RESUMEN

BACKGROUND: Drug-coated balloons (DCB) represent 1 of the most promising innovations in interventional cardiology and may represent a valid alternative to drug-eluting stents. Currently, some sirolimus-coated balloons (SCB) are being investigated for several coronary artery disease applications. OBJECTIVES: This study sought to understand the role of a novel SCB for the treatment of coronary artery disease. METHODS: EASTBOURNE (All-Comers Sirolimus-Coated Balloon European Registry) is a prospective, multicenter, investigator-driven clinical study that enrolled real-world patients treated with SCB. Primary endpoint was target lesion revascularization (TLR) at 12 months. Secondary endpoints were procedural success, myocardial infarction (MI), all-cause death, and major adverse clinical events (a composite of death, MI, and TLR). All adverse events were censored and adjudicated by an independent clinical events committee. RESULTS: A total population of 2,123 patients (2,440 lesions) was enrolled at 38 study centers in Europe and Asia. The average age was 66.6 ± 11.3 years, and diabetic patients were 41.5%. De novo lesions (small vessels) were 56%, in-stent restenosis (ISR) 44%, and bailout stenting occurred in 7.7% of the patients. After 12 months, TLR occurred in 5.9% of the lesions, major adverse clinical events in 9.9%, and spontaneous MI in 2.4% of the patients. The rates of cardiac/all-cause death were 1.5% and 2.5%, respectively. The primary outcome occurred more frequently in the ISR cohort (10.5% vs 2.0%; risk ratio: 1.90; 95% CI: 1.13-3.19). After multivariate Cox regression model, the main determinant for occurrence of the primary endpoint was ISR (OR: 5.5; 95% CI: 3.382-8.881). CONCLUSIONS: EASTBOURNE, the largest DCB study in the coronary field, shows the safety and efficacy of a novel SCB in a broad population of coronary artery disease including small vessels and ISR patients at mid-term follow-up. (The All-Comers Sirolimus-Coated Balloon European Registry [EASTBOURNE]; NCT03085823).


Asunto(s)
Angioplastia Coronaria con Balón , Enfermedad de la Arteria Coronaria , Reestenosis Coronaria , Infarto del Miocardio , Humanos , Persona de Mediana Edad , Anciano , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Enfermedad de la Arteria Coronaria/terapia , Enfermedad de la Arteria Coronaria/complicaciones , Angioplastia Coronaria con Balón/efectos adversos , Sirolimus/efectos adversos , Resultado del Tratamiento , Infarto del Miocardio/complicaciones , Sistema de Registros , Reestenosis Coronaria/diagnóstico por imagen , Reestenosis Coronaria/etiología
5.
Rev. ADM ; 79(3): 136-145, mayo-jun. 2022. ilus, tab, graf
Artículo en Español | LILACS | ID: biblio-1377862

RESUMEN

Durante la pandemia por COVID-19, la presencia de un incremento de fracturas y/o fisuras verticales ha sido reportada por Cirujanos Dentistas en diferentes países y foros, Objetivo: Determinar por medio de un análisis si existe una relación con este aumento de casos y la evolu- ción de la pandemia. Material y método: Se recopilaron los casos de fracturas verticales no restaurables durante el periodo de mayor índice de casos de contagio y defunciones por COVID-19 en la Ciudad de Chihuahua, México. Resultados: Durante el primer pico de casos y defunciones causadas por la pandemia, se incrementó el número de casos de fracturas verticales no tratables. Conclusiones: Existió una relación entre la evolución de la pandemia con la aparición de casos de fracturas dentales verticales no restaurables (AU)


During the COVID-19 pandemic, the presence of an increase in fractures and/or vertical fissures has been reported by Dental Surgeons in different countries and forums. Objective: To determine through an analysis, if there is a relationship with this increase in cases and the evolution of the pandemic. Material and methods: The cases of non-restorable vertical fractures were collected during the period of highest rate of cases of contagion and deaths due to COVID-19 in the City of Chihuahua, Mexico. Results: during the 1st peak of cases and deaths caused by the pandemic, the number of cases of untreatable vertical fractures increased. Conclusions: There was a relationship between the evolution of the pandemic and the appearance of cases of non-restorable vertical dental fractures (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Fracturas de los Dientes/epidemiología , COVID-19 , México/epidemiología , Tratamiento del Conducto Radicular , Raíz del Diente/lesiones , Fisuras Dentales/epidemiología , Distribución por Edad y Sexo , COVID-19/mortalidad , COVID-19/transmisión
6.
Obes Surg ; 32(4): 1289-1299, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35143011

RESUMEN

PURPOSE: The effectiveness of enhanced recovery after surgery (ERAS) pathways in patients undergoing bariatric surgery remains unclear. Our objective was to determine the effect of the ERAS elements on patient outcomes following elective bariatric surgery. MATERIALS AND METHODS: Prospective cohort study in adult patients undergoing elective bariatric surgery. Each participating center selected a single 3-month data collection period between October 2019 and September 2020. We assessed the 24 individual components of the ERAS pathways in all patients. We used a multivariable and multilevel logistic regression model to adjust for baseline risk factors, ERAS elements, and center differences RESULTS: We included 1419 patients. One hundred and fourteen patients (8%) developed postoperative complications. There were no differences in the incidence of overall postoperative complications between the self-designated ERAS and non-ERAS groups (54 (8.7%) vs. 60 (7.6%); OR, 1.14; 95% CI, 0.73-1.79; P = .56), neither for moderate-to-severe complications, readmissions, re-interventions, mortality, or hospital stay (2 [IQR 2-3] vs. 3 [IQR 2-4] days, 0.85; 95% CI, 0.62-1.17; P = .33) Adherence to the ERAS elements in the highest adherence quartile (Q1) was greater than 72.2%, while in the lowest adherence quartile (Q4) it was less than 55%. Patients with the highest adherence rates had shorter hospital stay (2 [IQR 2-3] vs. 3 [IQR 2-4] days, 1.54; 95% CI, 1.09-2.17; P = .015), while there were no differences in the other outcomes CONCLUSIONS: Higher adherence to ERAS Society® recommendations was associated with a shorter hospital stay without an increase in postoperative complications or readmissions. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03864861.


Asunto(s)
Cirugía Bariátrica , Recuperación Mejorada Después de la Cirugía , Obesidad Mórbida , Adulto , Cirugía Bariátrica/efectos adversos , Humanos , Tiempo de Internación , Obesidad Mórbida/cirugía , Readmisión del Paciente , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Estudios Prospectivos
7.
Rev. ADM ; 79(1): 12-19, ene.-feb. 2022. ilus, graf
Artículo en Español | LILACS | ID: biblio-1361307

RESUMEN

El objetivo del presente estudio fue medir la curvatura vestíbulo-lingual de los conductos de las raíces mesiales de primeros molares inferiores en personas adultas del estado de Chihuahua, por medio de la técnica de tomografía computarizada de haz cónico (CBCT, por sus siglas en inglés) y usando el software de análisis 3D EndoTM (Dentsply/Sirona USA). Se llevó a cabo la medición por dos observadoras, empleando dos métodos diferentes, Schneider y 3D EndoTM (Dentsply/Sirona USA). Los resultados obtenidos tuvieron valores mayores a los 100 grados con la técnica 3D EndoTM y a los 20 grados con la técnica de Schneider. No se detectó una diferencia estadística significativa al comparar los diferentes conductos entre sí (AU)


The objective of the present study was to measure the vestibule-lingual curvature of the ducts of the mesial roots of lower first molars, of adults from the state of Chihuahua. Using the cone beam computed tomography (CBCT) technique and using the 3D analysis software EndoTM (Dentsply/Sirona USA). The measurement was carried out by two observers using two different methods, Schneider and 3D EndoTM (Dentsply/Sirona USA). The results obtained had values greater than 100 degrees with the 3D EndoTM technique and at 20 degrees with the Schneider technique. No statistically significant difference was detected when comparing the different ducts with each other (AU)


Asunto(s)
Humanos , Cavidad Pulpar , Tomografía Computarizada de Haz Cónico , Diente Molar , Programas Informáticos , Imagenología Tridimensional , México
8.
Materials (Basel) ; 14(22)2021 Nov 17.
Artículo en Inglés | MEDLINE | ID: mdl-34832349

RESUMEN

Hydrogenated microcrystalline silicon (µc-Si:H) and epitaxial silicon (epi-Si) films have been produced from SiF4, H2 and Ar mixtures by plasma enhanced chemical vapor deposition (PECVD) at 200 °C. Here, both films were produced using identical deposition conditions, to determine if the conditions for producing µc-Si with the largest crystalline fraction (XC), will also result in epi-Si films that encompass the best quality and largest crystalline silicon (c-Si) fraction. Both characteristics are of importance for the development of thin film transistors (TFTs), thin film solar cells and novel 3D devices since epi-Si films can be grown or etched in a selective manner. Therefore, we have distinguished that the H2/SiF4 ratio affects the XC of µc-Si, the c-Si fraction in epi-Si films, and the structure of the epi-Si/c-Si interface. Raman and UV-Vis ellipsometry were used to evaluate the crystalline volume fraction (Xc) and composition of the deposited layers, while the structure of the films were inspected by high resolution transmission electron microscopy (HRTEM). Notably, the conditions for producing µc-Si with the largest XC are different in comparison to the fabrication conditions of epi-Si films with the best quality and largest c-Si fraction.

9.
Rev. ADM ; 78(3): 135-141, mayo-jun. 2021. ilus, tab, graf
Artículo en Español | LILACS | ID: biblio-1254493

RESUMEN

Se presentan los casos de fracturas verticales sintomáticos que ameritaron la extracción de las órganos dentales afectados en un periodo de cinco meses durante la pandemia por COVID-19 en la ciudad de Chihuahua, México. Material y métodos: Se recolectaron 26 muestras para el estudio, proporcionadas por los cirujanos dentistas integrantes del Grupo de Egresados de la Facultad de Odontología de la Universidad Autónoma de Chihuahua. Resultados: Los resultados muestran diferencias a lo reportado previamente respecto al tipo de diente involucrado, sexo de los pacientes, restauraciones coronales y tratamientos endodóncicos previos. Conclusiones: Se puede suponer que las modificaciones en el estilo de vida de la población, sumadas a la angustia permanente, pueden ser factores que contribuyen a las fracturas dentales (AU)


There are cases of symptomatic vertical fractures that warranted the extraction of affected teeth are presented, over a period of five months during the COVID-19 pandemic in Chihuahua City, Mexico. Material and methods: 26 samples were collected for the study, provided by the dentist who were members of the Graduate Group of the Faculty of Dentistry of the Autonomous University of Chihuahua. Results: The results show differences from what was previously reported regarding the type of tooth involved, sex of patients, coronal restorations and previous endodontic treatments. Conclusions: It can be assumed that changes in the lifestyle of the population, added to permanent distress, may be factors to preserve dental fractures (AU)


Asunto(s)
Fracturas de los Dientes/epidemiología , Raíz del Diente/lesiones , Infecciones por Coronavirus , COVID-19 , Tratamiento del Conducto Radicular/estadística & datos numéricos , Facultades de Odontología , Diente Premolar , Fisuras Dentales/epidemiología , Fotomicrografía , Técnica de Perno Muñón/estadística & datos numéricos , Corona del Diente/lesiones , Restauración Dental Permanente/estadística & datos numéricos , Distribución por Edad y Sexo , México/epidemiología , Diente Molar
10.
Artículo en Inglés | MEDLINE | ID: mdl-35002013

RESUMEN

sUAS (small-Unmanned Aircraft System) and advanced surface energy balance models allow detailed assessment and monitoring (at plant scale) of different (agricultural, urban, and natural) environments. Significant progress has been made in the understanding and modeling of atmosphere-plant-soil interactions and numerical quantification of the internal processes at plant scale. Similarly, progress has been made in ground truth information comparison and validation models. An example of this progress is the application of sUAS information using the Two-Source Surface Energy Balance (TSEB) model in commercial vineyards by the Grape Remote sensing Atmospheric Profile and Evapotranspiration eXperiment - GRAPEX Project in California. With advances in frequent sUAS data collection for larger areas, sUAS information processing becomes computationally expensive on local computers. Additionally, fragmentation of different models and tools necessary to process the data and validate the results is a limiting factor. For example, in the referred GRAPEX project, commercial software (ArcGIS and MS Excel) and Python and Matlab code are needed to complete the analysis. There is a need to assess and integrate research conducted with sUAS and surface energy balance models in a sharing platform to be easily migrated to high performance computing (HPC) resources. This research, sponsored by the National Science Foundation FAIR Cyber Training Fellowships, is integrating disparate software and code under a unified language (Python). The Python code for estimating the surface energy fluxes using TSEB2T model as well as the EC footprint analysis code for ground truth information comparison were hosted in myGeoHub site https://mygeohub.org/ to be reproducible and replicable.

11.
Cardiovasc Revasc Med ; 31: 1-6, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-33060037

RESUMEN

OBJECTIVES: We sought to evaluate clinical outcomes in patients treated with the drug-eluting stent ihtDEStiny BD. BACKGROUND: The ihtDEStiny BD stent is a metallic sirolimus eluting stent with a biodegradable polymer with both drug and polymer coating the abluminal surface of the stent and balloon. METHODS: In this study, the clinical outcomes of a multicenter prospective registry of patients treated with this stent (DEStiny group) were analyzed and compared with those of a control group of patients treated with durable polymer everolimus or zotarolimus eluting stents (CONTROL group) paired by propensity score matching. Primary outcome was the target vessel failure (TVF) at 12 months defined as a composite of cardiac death, target vessel myocardial infarction (TV-MI) and target vessel revascularization (TVR). RESULTS: A total of 350 patients were included in the DESTtiny group. The control group consisted initially of 1368 patients, but after matching (1:1) 350 patients were selected as CONTROL group. The baseline clinical, angiographic and procedural characteristics were quite comparable in both groups. At 12 months follow up the TVF was 6.6% in DEStiny group and 6.3% in CONTROL group (p = 0.8). No differences were observed for any of the individual components of the primary endpoint: cardiac death 1.1% vs. 1.4%, TV-MI 3.4% vs. 3.7% and TVR 2.6% vs. 2.3% respectively. CONCLUSIONS: The use of ihtDEStiny stent in real practice is associated with a clinical performance at 12 months follow up that appears to be non-inferior to the most widely used and largely evidence supported durable polymer drug eluting stents. A longer follow up is warranted.


Asunto(s)
Stents Liberadores de Fármacos , Intervención Coronaria Percutánea , Implantes Absorbibles , Everolimus/efectos adversos , Humanos , Intervención Coronaria Percutánea/efectos adversos , Polímeros , Puntaje de Propensión , Diseño de Prótesis , Sirolimus/efectos adversos , Sirolimus/análogos & derivados , Resultado del Tratamiento
12.
J Cardiovasc Med (Hagerstown) ; 22(2): 94-100, 2021 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-32740442

RESUMEN

AIMS: The purpose of the EASTBOURNE registry is to evaluate the immediate and long-term clinical performance of a novel sirolimus-coated balloon (SCB) in a real-world population of patients with coronary artery disease. We here present the prespecified interim analysis after the enrollment of the first 642 patients who obtained 1-year clinical follow-up. METHODS: EASTBOURNE is a prospective, international, multicenter, all-comer investigator-driven clinical registry, which is enrolling consecutive patients treated with SCB at 42 European and Asiatic centers. Primary study endpoint is target-lesion revascularization (TLR) at 12 months. Secondary endpoints are procedural success and major adverse cardiac events through 36 months. RESULTS: Diabetes mellitus was present in 41% of patients. Acute coronary syndrome was present in 45% of patients and de novo lesions were 55%; 83% of the in-stent restenosis (ISR) patients had drug-eluting stents restenosis. Lesion predilatation was performed in 95% of the cases and bailout stenting occurred in 7.5%. So far, 642 patients have a complete 12-month follow-up. TLR occurred in 2.5%, myocardial infarction in 2.3%, total death in 1% and major adverse cardiac events in 5.8% of patients. A prespecified analysis of comparison between ISR and de-novo lesions showed a significantly higher occurrence of TLR in the ISR population (5.4 vs. 0.2%, P = 0.0008). CONCLUSION: The current interim analysis of 12-month follow-up of the EASTBOURNE registry shows good immediate performance and an adequate and encouraging safety profile through 12 months for this novel SCB.


Asunto(s)
Angioplastia Coronaria con Balón/instrumentación , Materiales Biocompatibles Revestidos , Enfermedad de la Arteria Coronaria/cirugía , Stents Liberadores de Fármacos , Sistema de Registros , Sirolimus/farmacología , Anciano , Angiografía Coronaria , Enfermedad de la Arteria Coronaria/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Inmunosupresores/farmacología , Masculino , Estudios Prospectivos , Factores de Tiempo , Resultado del Tratamiento
13.
Educ. med. super ; 34(4): e2718, oct.-dic. 2020. ilus
Artículo en Español | LILACS, CUMED | ID: biblio-1154086

RESUMEN

Introducción: La respuesta dada por el Gobierno cubano y la ciencia a la situación epidemiológica que vivimos y al enfrentamiento de los problemas fundamentales del desarrollo del país, motiva a la reflexión y a un accionar más resuelto sobre qué se necesita hacer en el posgrado para contribuir con soluciones válidas, sostenidas, innovadoras y aplicables a esos problemas. Objetivos: Exponer algunas reflexiones y acciones ante el nuevo escenario generado por la COVID-19 y los problemas del desarrollo del país desde la perspectiva de la educación de posgrado. Posicionamiento del autor: El posgrado se enfrentará a problemas más complejos, al romperse las limitaciones disciplinares, sobre la base de sólidos fundamentos científicos y tecnológicos, lo que da lugar a soluciones innovadoras, estratégicas y comprometidas con la sociedad y su desarrollo en la construcción de un socialismo próspero y sostenible. Sin embargo, para lograr esto, la continuidad en la formación profesional del más alto nivel no es suficiente. Hay que considerar los disímiles procesos de ciencia, tecnología e innovación que tienen lugar en el posgrado, cuyos productos repercuten en el bienestar de la sociedad, en su desarrollo; de ahí su marcada y necesaria pertinencia. Conclusiones: El posgrado resulta necesaria y esencialmente innovador, por lo cual requiere de una mirada profunda y no concebirlo solo como el estudio del alto nivel, porque en este hay ciencia, tecnología, innovación y generación de conocimiento. Se requiere de acciones concretas emergentes con carácter acentuado ante el nuevo escenario creado por la COVID-19 y la necesidad de seguir desarrollando el país(AU)


Introduction: The response given by the Cuban Government and by science before the epidemiological situation we are going through, and before the confrontation of the fundamental concerns of the country's development, motivates reflection and more resolute action on what needs to be done in postgraduate studies to contribute to valid, sustained, innovative and applicable solutions to these problems. Objective: To present, from the perspective of postgraduate education, some reflections and actions in the face of the new circumstances produced by COVID-19 and the concerns regarding the country's development. Author's position: Postgraduate education will face more complex problems, by breaking disciplinary limitations, upon the basis of solid scientific and technological foundations, which gives rise to innovative, strategic solutions committed to society and its development in the construction of prosperous and sustainable socialism. However, to achieve this, continuity in professional training at the highest level is not enough. We must consider dissimilar processes of science, technology and innovation that take place in postgraduate studies, whose products have an impact on the well-being of society, as well as on its development; hence, its marked and necessary relevance. Conclusions: Postgraduate training is necessary and essentially innovative, a reason why it requires a deep look and not to be conceived only as high-level education, because it involves science, technology, innovation and generation of knowledge. Specific emerging actions are required, with an accentuated character based on the new circumstances created by COVID-19 and the need to continue developing the country(AU)


Asunto(s)
Humanos , Educación de Postgrado/organización & administración , Programas de Posgrado en Salud , Gestión del Cambio , Desarrollo de Personal , COVID-19
14.
Sensors (Basel) ; 20(9)2020 May 09.
Artículo en Inglés | MEDLINE | ID: mdl-32397557

RESUMEN

This work reports the development of arrays of infrared sensors (microbolometers) using a hydrogenated polymorphous silicon-germanium alloy (pm-SixGe1-x:H). Basically, polymorphous semiconductors consist of an amorphous semiconductor matrix with embedded nanocrystals of about 2-3 nm. The pm-SixGe1-x:H alloy studied has a high temperature coefficient of resistance (TCR) of 4.08%/K and conductivity of 1.5 × 10-5 S∙cm-1. Deposition of thermosensing film was made by plasma-enhanced chemical vapor deposition (PECVD) at 200 °C, while the area of the devices is 50 × 50 µm2 with a fill factor of 81%. Finally, an array of 19 × 20 microbolometers was packaged for electrical characterization. Voltage responsivity values were obtained in the range of 4 × 104 V/W and detectivity around 2 × 107 cm∙Hz1/2/W with a polarization current of 70 µA at a chopper frequency of 30 Hz. A minimum value of 2 × 10-10 W/Hz1/2 noise equivalent power was obtained at room temperature. In addition, it was found that all the tested devices responded to incident infrared radiation, proving that the structure and mechanical stability are excellent.

15.
Cardiovasc Revasc Med ; 21(4): 508-513, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-31401071

RESUMEN

OBJECTIVES: This study sought to assess the efficacy of the drug-coated balloon (DCB) ESSENTIAL for the treatment of in-stent restenosis (ISR). BACKGROUND: DCBs have proven a valid therapeutic option for the management of ISR in several clinical trials, yet no class effect can be claimed. Accordingly, every new DCB model has to be individually evaluated through clinical studies. METHODS: This is a prospective, multicenter study including consecutive patients undergoing percutaneous coronary intervention for ISR with the ESSENTIAL DCB. A 6-month quantitative coronary angiography (QCA)/optical coherence tomography (OCT) follow-up was scheduled. The primary endpoint was OCT-derived in-segment maximal area stenosis. Secondary endpoints included QCA-derived in-segment late lumen loss (LLL) and target lesion failure (TLF) rates at 6, 12, and 24 months. TLF was defined as the composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization. RESULTS: A total of 31 patients were successfully treated with DCB, with 67% of ISR corresponding to drug-eluting stents (DES). At 6 months, 26 patients underwent the scheduled angiographic follow-up. The mean value for in-segment maximal area stenosis was 51.4 ±â€¯13% and the median value was 53% (IQR 46.4-59.5). In the DES-ISR subgroup, these parameters were 52.6 ±â€¯10% and 55.2% (IQR 49.3-58.5), respectively. In-segment LLL was 0.25 ±â€¯0.43 mm with only 2 (7.7%) patients showing binary restenosis (>50%). The incidence of TLF was 10% at 6 months, 13.3% at 12 months, and 13.3% at 24 months. CONCLUSIONS: In this study, the ESSENTIAL DCB showed sustained efficacy in the prevention of recurrent restenosis after treatment of ISR. SUMMARY: We sought to assess the efficacy of the drug-coated balloon ESSENTIAL for the treatment of in-stent restenosis through a prospective, multicenter study including QCA and OCT assessment at 6-month follow-up. The primary endpoint was in-segment maximal area stenosis. Among the 31 patients successfully treated with the ESSENTIAL DCB, an angiographic follow-up was conducted in 26. Mean in-segment maximal area stenosis was 51.4 ±â€¯13% and the median value was 53% (IQR 46.4-59.5). In the DES-ISR subgroup, corresponding values were 52.6 ±â€¯10% and 55.2% (IQR 49.3-58.5), respectively. The observed in-segment LLL was 0.25 ±â€¯0.43 mm and binary restenosis rate was 7.7%. TLF was 10% at 6 months and 13.3% at 12 and 24 months.


Asunto(s)
Angioplastia Coronaria con Balón/instrumentación , Fármacos Cardiovasculares/administración & dosificación , Materiales Biocompatibles Revestidos , Angiografía Coronaria , Enfermedad de la Arteria Coronaria/terapia , Reestenosis Coronaria/terapia , Vasos Coronarios/diagnóstico por imagen , Paclitaxel/administración & dosificación , Intervención Coronaria Percutánea/instrumentación , Stents , Tomografía de Coherencia Óptica , Anciano , Angioplastia Coronaria con Balón/efectos adversos , Angioplastia Coronaria con Balón/mortalidad , Fármacos Cardiovasculares/efectos adversos , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Enfermedad de la Arteria Coronaria/mortalidad , Reestenosis Coronaria/diagnóstico por imagen , Reestenosis Coronaria/etiología , Reestenosis Coronaria/mortalidad , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Paclitaxel/efectos adversos , Intervención Coronaria Percutánea/efectos adversos , Intervención Coronaria Percutánea/mortalidad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Factores de Riesgo , España , Resultado del Tratamiento
16.
Rev. Asoc. Esp. Espec. Med. Trab ; 28(1): 65-75, mar. 2019.
Artículo en Español | IBECS | ID: ibc-185827

RESUMEN

Cuando el deporte se realiza como actividad profesionalizada, convierte a quien lo practica en un trabajador que queda sujeto, por tanto, a la normativa preventiva, especialmente si implica requerimientos físicos de alto nivel y posibles consecuencias en la salud. Objetivos: realizar una revisión de la bibliografía médica para conocer los riesgos más prevalentes en deporte profesional, valorando lesiones y aspectos preventivos, con una consideración especial a los colectivos de menores, mujeres y personas con discapacidad. Material y Métodos. se realiza una búsqueda en Medline de la bibliografía médica relacionada con deporte profesional, sin periodo de tiempo acotado y utilizando los descriptores: professional sport and risk, prevention, occupational health, overuse injuries, gender differences, and disability, and youth athletes. Resultados: se detecta la escasez de estudios epidemiológicos en este campo, la necesidad de especialización de los profesionales y de una coordinación adecuada entre todos los sanitarios implicados para obtener una prevención más efectiva y eficaz. Los especialistas en Medicina del Trabajo deben ser una pieza clave en los aspectos de Vigilancia de la Salud del profesional del deporte, tanto en prevención individual como colectiva, que vienen recogidas en la legislación española y en el marco jurídico común de la Unión Europea


When the sport is performed as a professional activity, it turns the person who practices it into a worker subject, therefore, to preventive regulations, especially if it involves high-level physical requirements and possible health consequences. Objectives: to carry out an annotated review of the medical literature about professional sports assessing risks, injuries and preventive aspects, with special consideration to groups of minors, women and people with disabilities. Material and Methods: a search is made in Medline about medical literature related to professional sports without a limited period of time, and using the descriptors: professional sport and risk, prevention, occupational health, overuse injuries, gender differences, and disability, and youth athletes. Results: there is a lack of epidemiological studies in this field, the need for professional specialization and adequate coordination among all health professionals involved to obtain a more effective and efficient prevention. The specialists in Occupational Medicine must be a key element in the aspects of health surveillance of the professional sport, both in individual and collective prevention, as reflected in Spanish legislation and in the common legal framework of the European Union.Key words: medical bibliography, sport injuries, prevention and control


Asunto(s)
Humanos , Femenino , Adolescente , Traumatismos en Atletas/epidemiología , Enfermedades Profesionales/epidemiología , Factores de Riesgo , Prevalencia
17.
Fed Pract ; 35(9): 24-26, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30766383

RESUMEN

Consider flexible bronchoscopy as an option to retrieve aspirated foreign bodies in the airway.

18.
Colorectal Dis ; 2017 Dec 06.
Artículo en Inglés | MEDLINE | ID: mdl-29211327

RESUMEN

A correct preoperative strategy is crucial when surgery is needed for retrorectal tumours (RRT).[1] Surgical approaches may be purely anterior-abdominal, posterior-sacrococcygeal or combined depending on the tumour's size and location.[2] We present the case of an 18-year-old female with Currarino Syndrome who underwent surgery by a combined abdominal laparoscopic-posterior Kraske approach for the resection of a large RRT. This article is protected by copyright. All rights reserved.

19.
Rev. iberoam. fertil. reprod. hum ; 34(2): 23-27, abr.-jun. 2017. ilus
Artículo en Español | IBECS | ID: ibc-165325

RESUMEN

Paciente de 36 años con esterilidad primaria de 2 años. Tras estudio completo se decide donación de ovocitos. En los controles se observa un grosor endometrial adelgazado. Con el diagnóstico de endometrio refractario, se realiza un tratamiento con estrógenos a altas dosis, vitamina E y pentoxifilina durante 3 meses. Como el grosor endometrial no aumenta, asociamos AAS. Finalmente se administra intraútero plasma autólogo rico en plaquetas. A las 96 horas se observa un endometrio de 7,3 mm, transfiriéndose dos embriones vitrificados, resultando en un aborto bioquímico. Discusión: El tratamiento médico del endometrio refractario constituye un reto. Existen numerosas opciones terapéuticas, hormonales y no hormonales. Sin embargo, la mayoría de estas opciones están escasamente evaluadas por lo que se requieren de estudios mejor diseñados y con mayor tamaño muestral (AU)


36 years old patient with primary sterility of 2 years. An oocyte donation was decided after the study. An endometrial thickness slimmed was observed in different visits. With the diagnosis of refractory endometrium, a treatment was performed with high-dose estrogen, vitamin E and pentoxifylline for 3 months. As the endometrial thickness did not increase, we associated AAS. Finally intrauterine platelet-rich autologous plasma was administered. At 96 hours 7.3 mm of endometrium was observed, two vitrified embryos transferred, resulting in a biochemical abortion. Discussion: The medical treatment of refractory endometrium is a challenge. There are many therapies, hormonal and nonhormonal options. However, most of these options are poorly evaluated so they require better designed studies and larger sample size (AU)


Asunto(s)
Humanos , Femenino , Adulto , Plasma Rico en Plaquetas , Infertilidad Femenina/terapia , Endometrio/fisiopatología , Salpingectomía , Técnicas Reproductivas Asistidas , Ginatresia/complicaciones
20.
Rev Esp Enferm Dig ; 109(5): 372, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28480725

RESUMEN

Omental torsion is an infrecuent cause of acute abdomen. It is related to obesity, abdominal surgery and abdominal trauma. Urgent exploratory laparotomy allows diagnosis and prevents complications as intrabdominal abcess. We present CT imaging of a Omenat torsion clinical case.


Asunto(s)
Dolor Abdominal/etiología , Epiplón/diagnóstico por imagen , Enfermedades Peritoneales/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Anomalía Torsional/diagnóstico por imagen , Anciano , Humanos , Masculino , Enfermedades Peritoneales/complicaciones , Anomalía Torsional/complicaciones
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...